Treatment effect for the coprimary and key secondary efficacy end points. (A) Treatment difference is estimated for ravulizumab-eculizumab. For the TA end point, treatment differences (Diff) (95% CI) are based on estimated differences in percent with 95% CI. For the LDH normalization (LDH-N) end point, adjusted prevalence within each treatment is displayed. *Red triangle indicates the noninferiority margin. (B) For key secondary end points LDH-PCHG (percent change), breakthrough hemolysis (BTH), and hemoglobin stabilization (HGB-S), Diff (95% CI) is based on estimated differences in percent with 95% CI. For FACIT-Fatigue, Diff (95% CI) is based on estimated differences in change from baseline with 95% CI. *Red triangle indicates the noninferiority margin. †Treatment difference is estimated for ravulizumab-eculizumab except for LDH-PCHG and BTH, where treatment difference is based on eculizumab-ravulizumab. ‡P < .06 for the lower bound of the 95% CI.