Heatmaps for significant differential gene expression between GCB and ABC subtypes classified by Affymetrix GeneChip or RNA-seq. (A) RNA-seq expression data (significant genes with FDR < 0.10 and fold change ≥ 1.42) of previous GCB/ABC subtypes classified by Affymetrix GeneChip DNA microarray data. (Bi) RNA-seq expression data (top 46 genes selected for the new NGS-COO classifier) of the new GCB/ABC groups. (Bii) Affymetrix GeneChip microarray data of the new GCB/ABC groups.