The donor rs1051792 A allele in MICA is associated with lower risk of NRM after allogeneic HCT, lower risk of grade 3 to 4 acute GVHD, and lower risk of NRM among patients with grade 3 to 4 acute GVHD. (A) NRM among patients in the replication cohort, according to the donor rs1051792 genotypes. (B) NRM among patients in the replication cohort, according to the recipient rs1051792 genotypes. (C) Grade 3 to 4 GVHD among patients in the combined discovery and replication cohorts, according to the donor rs1051792 genotypes. (D) Grade 3 to 4 GVHD among patients in the combined discovery and replication cohorts according to the recipient rs1051792 genotypes. (E) NRM from the onset of GVHD among patients with grade 3 to 4 GVHD in the combined discovery and validation cohorts, according to the donor rs1051792 genotypes. (F) NRM from the onset of GVHD among patients with grade 3 to 4 GVHD in the combined discovery and validation cohorts, according to the recipient rs1051792 genotypes. Differences according to donor and recipient genotypes partly reflect different sets of donor-recipient pairs and cannot be attributed entirely to the respective genomes of the donors and recipients.