American Society of Hematology

Figure 1.

Manhattan plots show recipient and donor SNP associations with NRM and RM in the discovery cohort. Each panel shows the −log10(P value) for post-QC variants with MAF >1% for autosomes and chromosome X. The results in each panel represent 6.47 × 106 variants. The solid line shows genome-wide significance (5 × 10−8). The dotted line shows the threshold used to select variants for replication (10−6). Vertically aligned associations reflect variants that are strongly correlated by linkage disequilibrium. Recipient genome inflation values29 were 1.005 for NRM and 1.026 for RM, and donor genome inflation values were 1.030 for NRM and 1.009 for RM.

Manhattan plots show recipient and donor SNP associations with NRM and RM in the discovery cohort. Each panel shows the −log₁₀(P value) for post-QC variants with MAF >1% for autosomes and chromosome X. The results in each panel represent 6.47 × 10⁶ variants. The solid line shows genome-wide significance (5 × 10⁻⁸). The dotted line shows the threshold used to select variants for replication (10⁻⁶). Vertically aligned associations reflect variants that are strongly correlated by linkage disequilibrium. Recipient genome inflation values²⁹ were 1.005 for NRM and 1.026 for RM, and donor genome inflation values were 1.030 for NRM and 1.009 for RM.

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