WM subgroups show differential biological features. (A) Oncoprint of genomic aberrations in WM separated by methylation subtype. Epigenetic maturity (as defined in Figure 3) is indicated for each sample; bars below and above represent low and high maturity, respectively. Mutations were mostly clonal VAFs (black) with a minority of subclonal mutations observed (VAF <10%; dark gray). (B) The proportion of patients with IGHV1-6 rearrangements separated by methylation subtype. (C) Box plot of the mean fluorescence intensity of CD38 on WM tumor cells separated by methylation subtype, gated on CD19⁺ and monotypic light chain–restricted cells. (D) Summary of tumor cell morphology of WM patient BM samples. Percentages of cell types were averaged within WM methylation subtypes. n.s., not significant.