Figure 6.
![Examples of disease cohort indexing. Multivariable representations of individual patient samples in the context of the analyzed disease cohorts. (A) Two patients with stable disease (ET [patient 1] and refractory PV [patient 2]) in whom sequential samples were available showed close clustering of the analyzed samples on the PCA plot. (B) Two patients with transformed ET (patient 3) and PV (patient 4) showed a marked shift in the multivariable representations of megakaryocytes between the chronic MPN samples and the transformed samples (post-ET myelofibrosis and post-PV myelofibrosis, respectively) on the PCA plot. The confidence level indicates the likelihood of samples belonging to a particular MPN classification.](https://ash.silverchair-cdn.com/ash/content_public/journal/bloodadvances/4/14/10.1182_bloodadvances.2020002230/1/advancesadv2020002230f6.png?Expires=1724238494&Signature=ySUh8WtUIM2h4rGj65Xh6ixA~c12-4iG2KXO1qvhHf7R~YuPqhh9vTFH3Ys1CYg15YLr7ULPDa6QcVuk41ATedNdZWFkuTIIVUzu~RAIfiGxkWiz~TxzTJyYqmtrZhJBs1rOdS6ID0X2iC8cKDILTo6Zihri1EXDeLiVGJuCzG3cBIb34OyRQimgqaHlnZumJPqyZLP5LJQ2g7kDFx-WTpBpTxJgnwYCR~f12gFtl3lffnQuv5uwBzGnfir~w60FESMKZZ1K1Dy~GDto9idTrdYF~DGMDG7IkYEgbudVyaymBmkmNBfMOZXIz-DVnN2Dz5jDb~BOlyTYsqBIK-oyfA__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Examples of disease cohort indexing. Multivariable representations of individual patient samples in the context of the analyzed disease cohorts. (A) Two patients with stable disease (ET [patient 1] and refractory PV [patient 2]) in whom sequential samples were available showed close clustering of the analyzed samples on the PCA plot. (B) Two patients with transformed ET (patient 3) and PV (patient 4) showed a marked shift in the multivariable representations of megakaryocytes between the chronic MPN samples and the transformed samples (post-ET myelofibrosis and post-PV myelofibrosis, respectively) on the PCA plot. The confidence level indicates the likelihood of samples belonging to a particular MPN classification.