Efficiency of the assisted tool for megakaryocyte identification. Our Web-based interface for assisted annotation. (A) Candidate megakaryocytes are automatically identified by the AI algorithm, allowing hematopathologists to quickly review and confirm these as megakaryocytes (green boxes) or nonmegakaryocytes (red boxes). The human-in-the-loop assisted annotation achieved a high level of accuracy as measured by the mean average precision (mAP) within a few training iterations (B), and the annotation time was significantly reduced (C) (Wilcoxon rank-sum test, significance level 0.05).