Retrospective analysis of HBV reactivation in patients with different HBV serologic statuses. Among the 89 patients who had received a diagnosis of B-ALL or B-NHL, 21 received ETV prophylaxis, including all of the HBsAg⁺ patients and 2 of the HBsAg⁻/HBcAb⁺ patients. These 2 patients were also seropositive for HBsAb. HBV reactivation was detected in 1 patient with chronic HBV infection. Except for this patient, no patient in each subgroup had HBV reactivation, severe hepatitis, or HBV-related mortality. *Includes 1 patient seropositive for anti-HCV IgG, in whom HCV-RNA was undetectable. †Includes 1 patient seropositive for anti-HEV IgG, but negative for anti-HEV IgM. HCV, hepatitis C virus; HEV, hepatitis E virus.