Transcriptional network of mature neutrophils is epigenetically deregulated in MM. (A) Correlation between gains and losses of chromatin accessibility near TSSs and gene expression for each sample. Significant positive correlation between MM-induced changes in gene expression level and chromatin accessibility at gene promoters in mature granulocytes (P = 8.17e−6). (B) Gene ontology enrichment analysis of differentially expressed genes underscores functions related to neutrophil activation in MM. (C) Transcriptional analysis of mature neutrophils from MM patients (n = 3) treated with CM-272–segregated samples according to exposure and concentration of the drug. (D) Gene ontology enrichment analysis based on upregulated genes in mature neutrophils from MM patients after treatment with CM-272. FC, fold-change.