Clinical significance of granulocytes in the tumor microenvironment. (A) Unbiased immune monitoring of the tumor microenvironment based on uniform manifold approximation and projection (UMAP) of BM samples of newly diagnosed MM patients (n = 55). (B) Unsupervised clustering of MM patients based on cellular composition of the tumor microenvironment. (C) PFS according to high (>32%) vs low (≤32%) abundance of mature (CD11b⁺CD13⁺CD16⁺) neutrophils (3-year PFS rate, 66% vs 79%, respectively; P = .0391). (D) PFS according to high (>3.4) vs low (≤3.4) mature neutrophil/T-lymphocyte ratio (3-year PFS rate, 60% vs 85%, respectively; P < .0001). NK, natural killer; NRBC, nucleated red blood cell.