Incidence of different HMs and frequently co-occurring mutations associated with germline TF mutations. Incidence of HMs (first presentation) by age group associated with germline mutations in RUNX1 (n = 123) (A), GATA2 (n = 312) (B), and CEBPA (n = 58) (C). Circos plot showing the relative percentages of frequently co-occurring somatic alterations (mutations and cytogenetic abnormalities) in patients with germline mutations in RUNX1 (D), GATA2 (E), and CEBPA (F). The variables are arranged clockwise in descending order from the most frequent to the least frequent and are distinguished by different colors. The inner circle shows the absolute number of samples with mutations in each gene as indicated. The outer circle shows the percentage of cases with comutation of other genes (indicated by designated gene color from inner circle) for each gene. Co-occurring alterations are also shown as paths emerging from 1 to the other with widths proportional to the number of cases. ALL, acute lymphoblastic leukemia (including T- and B-cell subtypes); AUL, acute undifferentiated leukemia; B-ALL, B-cell acute lymphoblastic leukemia; chr5, del5q; chr7, monosomy 7, del 7q or der (1;7); chr8, trisomy 8; chr21, trisomy 21; Cyto, cytogenetic changes; CLL, chronic lymphocytic leukemia; CML, chronic myeloid leukemia; CMML, chronic myelomonocytic leukemia; HCL, hairy cell leukemia; JMML, juvenile monocytic leukemia; NHL, non-Hodgkin lymphoma; T-ALL, T-cell acute lymphoblastic leukemia. See supplemental References (available on the Blood Web site).