RNAseq analysis of the spleen of Hbb^th3/+and Tfr2^BMKO/Hbb^th3/+mice. (A) Gene ontology (GO) analysis relative to the biological function of the differentially expressed genes (FDR < 10% and log2 fold change less than −0.5 for the downregulated; FDR < 10% and log2 fold change > 0.5 for the upregulated) of Tfr2^BMKO/Hbb^th3/+ mice vs Hbb^th3/+. (B) Heatmap representation of the differentially expressed genes belonging to the single biological processes represented in panel A.