Relationship between subclonal and clonal TP53 deletion and clinical and genetic characteristics of myeloma. Percentage frequency of genetic changes (A) and clinical changes (B) associated with low, intermediate, and high deletion of TP53 clone. (C) MLPA values normalized for 13q probes in the same patients with low, intermediate, and high deletion of TP53 clone. (D) MLPA values across the subset of patients with del(TP53) and increasing size of del(13q) clone. Lower MLPA values represent increasing size of deleted clone.