UCHL1 levels strongly correlate with increased MYC target expression. (A). Levels of UCHL1 and MYC as measured in 324 independent RNA expression profiles. Note the lack of a positive association with MYC levels. Each point represents the mean ± standard error of the mean expression of MYC and UCHL1 from 1 data set. (B-C) Gene set enrichment analysis was performed using the parametric analysis of gene set enrichment in 5 data sets, including at least 100 primary samples of mature B-cell lymphoma (Burkitt or Diffuse large B-cell). Shown are the Z scores for MYC target genes comparing UCHL1^HI (>80%) versus UCHL1^LO (0%-79%; B) and the systematic skewing favoring higher MYC target levels in UCHL1^HI cases (note how most genes fall on the right side of the line; C) and the heat map demonstrating higher expression of MYC targets in the UCHL1^HI cases (pink) compared with UCHL1^LO (blue).