Altered DNA methylation explains a minority of gene-expression changes after Dnmt3a loss. (A) Venn diagram showing overlap of gene significantly hypomethylated between compared data sets.^24,26,43  (B) Venn diagram showing overlap between the hypomethylated gene core and the DNMT3A gene-expression core. (C) GSEA plot representing PRC2 complex regulated genes in edited LSK from Jak2^VF-Dnmt3a-Cas9 and Jak2^VF-Cas9 recipient mice. (D-G) GSEA plot representing PRC2 complex (EED, EZH2, and SUZ12) in edited LSK from Jak2^VF-Dnmt3a-Cas9 and Jak2^VF-Cas9 recipient mice.