Mutation patterns in genes enriched for mutations within the population of rrDLBCLs. Lollipop plots displaying the mutations discovered in the 6 genes (KMT2D [A], TP53 [B], CREBBP [C], FOXO1 [D], NFKBIE [E], MS4A1 [F]) found to be significantly enriched for mutations at relapse compared with untreated DLBCL. Mutations in rrDLBCL are displayed above each gene, and mutations in the untreated cohort are displayed below each gene. The number of mutated cases and percentage of cases with mutations in that gene are shown beside each gene (red: relapse; blue: untreated). The size of a lollipop and vertical displacement represent the number of patients with nonsilent mutations observed at that position. Note that lollipops were scaled down in the untreated cohort, and thus, the size of a lollipop cannot be directly compared between the untreated and relapse cohorts. Relevant protein domains are displayed for genes with differing mutation patterns within these domains. There is a general enrichment for recurrent mutations in the untreated cohort, most pronounced in KMT2D. These are attributed to rare germline variants that we were unable to filter due to their absence in any database of common variants.