Men have a higher prevalence of non–MPN-specific somatic mutations and particularly 1 or 2 HRMs independent of age and phenotype at the time of NGS. (A) Higher percentage of women have no non–MPN-specific somatic mutations, whereas a higher percentage of men have ≥1 non–MPN-specific somatic mutations if stratified per age (≤60 years and >60 years). (B) Men have a higher prevalence of mutations in the high-risk genes ASXL1, SRSF2, U2AF1, EZH2, IDH1, and IDH2. (C) Men have a higher incidence of at least 1 HRM (P = .017) and 2 HRMs (P = .011) compared with women, independent of age and phenotype at the NGS and MPN-specific mutation.