Figure 1.
Illustration of the role of Hp in inhibiting extravasation of LMW PolyHb species. (A) Hb (1) binds with Hp (2), which significantly increases the size of the resulting Hb-Hp complex (3). Similarly, PolyHb (4) can bind with Hp (2) to form a PolyHb-Hp complex with increased molecular diameter. (B) In circulation, LMW PolyHb (6) can freely extravasate from the blood (7) through the endothelial cell wall (8) via the endothelial gap junction (9). Once past the endothelial wall, the extravasated PolyHb (10) accumulates in the intima (11) where it scavenges the NO produced by the endothelial cells that regulate smooth muscle cell (12) contraction. (C) When PolyHb binds to Hp, the resulting PolyHb-Hp complexes (13) are too large to pass through the endothelial gap junction. This effectively limits PolyHb extravasation into the tissue space and NO scavenging.

Illustration of the role of Hp in inhibiting extravasation of LMW PolyHb species. (A) Hb (1) binds with Hp (2), which significantly increases the size of the resulting Hb-Hp complex (3). Similarly, PolyHb (4) can bind with Hp (2) to form a PolyHb-Hp complex with increased molecular diameter. (B) In circulation, LMW PolyHb (6) can freely extravasate from the blood (7) through the endothelial cell wall (8) via the endothelial gap junction (9). Once past the endothelial wall, the extravasated PolyHb (10) accumulates in the intima (11) where it scavenges the NO produced by the endothelial cells that regulate smooth muscle cell (12) contraction. (C) When PolyHb binds to Hp, the resulting PolyHb-Hp complexes (13) are too large to pass through the endothelial gap junction. This effectively limits PolyHb extravasation into the tissue space and NO scavenging.

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