Gene coexpression analysis in GATA2 deficiency. (A) Gene correlation distribution in healthy donors (pink; 0.390 ± 0.003) and patients (blue; 0.480 ± 0.110) The x-axis shows gene correlation score after imputations with MAGIC. The y-axis shows frequency. (B) A bar graph shows comparison of average correlation scores in patients with those in healthy donors. (C) A comparative correlation heatmap shows correlation between pairs of genes ranging from negative correlation (blue) to positive correlation (red) in healthy donors (upper left) and patients (lower right). The upper panel shows unsupervised modules of differentially coexpressed genes defined by weighted gene coexpression network analysis. Modules of genes are distinguished by colors. GO terms for each module of genes identified in the coexpression matrix are listed. Detailed information of individual gene modules is presented in supplemental Table 7. (D) Gene coexpression networks enriched in the KEGG_MTOR signaling pathway (left), the T-cell receptor signaling pathway (middle), and the B-cell receptor signaling pathway (right). Gene correlation networks are illustrated as the difference between patients and healthy donors.