CD34⁺ BC progenitors exhibit transcriptional convergence. (A) Heat map of statistically significant (Log2 fold-change > 0.58 or < −0.58 and adjusted P < .05) gene expression differences between CD34⁺ MBC (n = 13), LBC (n = 5), and CP (n = 16) progenitors. Mutational profiles of the commonest recurring gene mutations are depicted for each transcriptome. All ABL1 mutations are in the 3′ part of the gene belonging to BCR-ABL1. *Biphenotypic BC sample with myeloid and lymphoid immunophenotype (“Methods”). (B) Enriched and depleted MSigDB v6.1 hallmark gene sets within the MBC gene expression networks. (C) GSEA-based network analysis for LSC gene set signatures within MBC transcriptomes. (D-E) PRC1 and PRC2 pathway gene set signatures within MBC by GSEA.