Logos displaying the binding motifs for HLA-DR molecules encoded by DRB1*08:03 and DRB1*11:01. The numbers shown on the x-axis indicate different pocket motifs. Each letter represents the abbreviation of an amino acid. Basic, acidic, and neutral amino acids are shown in blue, red, and green, respectively. The height of each column of letters is equal to the information content at the given position in the binding motif. The relative height of each letter within each column reflects the percentile of the frequency of each amino acid at that pocket. Pocket motifs 1, 4, 6, 7, and 9, circled in red, play essential roles in peptide binding after antigen presentation. This figure shows that the peptide-binding motif of DR molecules encoded by HLA-DRB1*08:03 (A) may differ from that of DR molecules encoded by HLA-DRB1*11:01 (B).