Patient weight over the first 2 cycles and days on study as functions of selinexor dose. (A) Average patient weight ± standard error of the mean (SEM) at various time points over the first 2 cycles is depicted for patients treated with ≤40 mg/m² (open squares, solid fit line) and >40 mg/m² (open circles, dashed fit line). Curves were fit with GraphPad software using a 1-phase decay equation. The curves differ significantly (P < .001) by dose proportionality (F test). The number of patients with available body weight measurements at each time point (day) is located next to each open circle or open square. (B) Average days on study ± SEM for patients treated with ≤40 mg/m² (red bar; n = 46) and >40 mg/m² (white bar; n = 33). The bars differ significantly (P = .005) by Student t test.