Unsupervised clustering of the cHL, GZL, polymorphic-EBV-L, and PMBCL samples based on the main biological pathways. Pathways were identified by using preranked GSEA of genes ordered by their correlation with PC1 or PC2 scores. The top 10 genes included in the core set of the significant pathways were selected. The pathways were grouped into functional categories including cell cycle (high in PMBCL and group 3), epithelial-mesenchymal transition (EMT)/matrisome/extracellular matrix (ECM), cellular microenvironment (NK cells, T cells/allograft rejection, IFN), and humoral response. Unsupervised clustering of the samples based on expression of these pathway genes revealed a spectrum with PMBCL and group 3 at one extreme, and cHL cases mixed with GZL groups 0, 1, and 2.