MYC suppression correlates with primary ibr sensitivity. (A) GSEA of MYC gene signature³³  in JEKO and MAVER cells after treatment with either 0.4 µM of ibr for 6 hours or DMSO. False discovery rate (FDR) and P values are indicated. (B) Heat map showing differential gene expression in top-ranked genes from MYC signature in JEKO and MAVER cells after treatment with either 0.4 µM of ibr for 6 hours or DMSO. Biological triplicate experiments were conducted and represented by 3 columns for each condition. (C) Table summarizing the changes in MYC signature in relation to cellular response to ibr. (D) Confirmatory GSEA using a different set of MYC signature genes.³⁴