Phylogenetic relationship between different lesions in the same patient: topologic heterogeneity in MF. Pairs of LSP and tumor (TMR) biopsies were collected from 6 patients and analyzed as in Figure 4. Red branches represent TMR (T), green branches symbolize evolution of the LSP (P). Blue circles represent common clones shared by TMRs and LSPs (C). Black circle represents a phylogenetic tree without an identifiable ancestor clone.