Distribution of mutations in the stem and clades in MF. (A) Percentage of all SNV mutations in the stem (blue) and clades (red) of the phylogenetic tree. (B) Mutational landscape of the putative driver genes in the stem and clades of the phylogenetic tree. Black square indicates a function-changing mutation (missense, frameshift, insertion, deletion, stop gain or loss, or variant in 3′ or 5′ untranslated region). Mutations of the same gene found both in the stem and clades signify different positions of the mutation. TMR, tumor.