Genomic copy-number changes in MF. (A) Heatmap showing copy-number changes for the 49 MF samples separated by type of lesion (ESP, LSP, tumor [TMR]). Red bars indicate amplifications; blue bars indicate deletions. Numbers of amplifications and deletions are presented on a log2 scale. Bar charts at the top show the difference in numbers of amplifications (+1 per sample) or deletions (−1 per sample) at each chromosome across lesion types. (B) Difference in numbers of amplifications or deletions for putative driver genes in each subgroup of MF samples.