Mutational landscape of putative driver genes in MF. (A) Number of nonsynonymous SVs in ESP, LSP, and tumor (TMR) samples. Box-and-whisker plot showing 90th percentile, respectively. Filled square indicates 10th percentile; filled triangle indicates 90th percentile. (B) Identification of amino acid–altering mutations in 75 putative driver genes across 21 different pathways. Black gene symbols annotate the previously reported 47 driver genes in CTCL; the previously unreported 28 potential drivers identified in this study are highlighted in blue. Damaging mutations indicate frameshift mutations, short read insertion and deletion (<6 bp), stop gain, or stop loss.