Rux treatment in the MISTRG MF PDX model. (A) Workflow of the experimental treatment plan with control (vehicle) or Rux. (B) Total human engraftment in the BM, PB, and SPL of MISTRG mice 21 days after treatment with vehicle or Rux. (C) SPL weight of MISTRG mice 21 days after treatment with vehicle or Rux. (D) Percentage of human B-lymphoid and myeloid cells among total engrafted human cells in the BM, PB, and SPL after vehicle or Rux treatment. *P < .05; **P < .01 (unpaired Student t test).