Figure 2.
VST product characteristics. (A) Cell yields after manufacture using APCs either transduced with the Ad5f35-pp65 vector (ACT-CAT) or cocultured with overlapping viral peptides (ACT-CAT2). (B) VST products demonstrated multivirus specificity as measured by IFN-γ ELISPOT assay in response to CMV, EBV, and adenovirus antigen. Data for 19 VST products is represented as the number of SFCs per 100 000 after subtracting the values of the actin negative control. (C) A CD4+ T-cell predominant phenotype was observed with similar effector memory (CD45RA–/CD62L–) and central memory (CD45RA–/CD62L+) percentages in the VST products. Memory phenotype data were not available for products P0020, P0035, P0039, P005, and P0067 because of limited product availability for analysis after infusion.

VST product characteristics. (A) Cell yields after manufacture using APCs either transduced with the Ad5f35-pp65 vector (ACT-CAT) or cocultured with overlapping viral peptides (ACT-CAT2). (B) VST products demonstrated multivirus specificity as measured by IFN-γ ELISPOT assay in response to CMV, EBV, and adenovirus antigen. Data for 19 VST products is represented as the number of SFCs per 100 000 after subtracting the values of the actin negative control. (C) A CD4+ T-cell predominant phenotype was observed with similar effector memory (CD45RA–/CD62L–) and central memory (CD45RA–/CD62L+) percentages in the VST products. Memory phenotype data were not available for products P0020, P0035, P0039, P005, and P0067 because of limited product availability for analysis after infusion.

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