New molecular subtypes of de novo MPAL. (A) Graphic demonstration of mutant alleles of PHF6 gene (1 patient had splicing site mutation not illustrated here). (B) New MPAL classification with incorporation of our genetic discoveries. (C-D) Overall survival (C) and relapse-free survival (D) of PHF6 mutated vs DNMT3A unmutated vs others without PHF6 or DNMT3A mutations.