Prevalence and distribution of somatic mutations. (A) Description of the cohort (n = 1887). (B) Prevalence of the 540 somatic mutations identified in 427 individuals of the cohort. (C) Mutation signature of all single nucleotide substitutions (supplemental Figure 2). (D) VAF distribution of all somatic mutations. (E) Cooccurrence of the all somatic mutations in the 427 mutated individuals. Darker shades represent double mutation in the same gene. (F) Contribution of individual genes to the total number of observed somatic mutations. (G) Average VAF of somatic mutation for each gene.