Diagnostic and therapeutic proposals for optimization of HCT in WAS. aGVHD, acute graft-versus-host-disease; BM, bone marrow; Bu, busulfan; CB, cord blood; cGVHD, chronic graft-versus-host-disease; D, donor; EBV, Epstein Barr virus; GF, graft failure; haplo, haploidentical; MAC, myeloablative conditioning; PBSC, peripheral blood stem cells; R, recipient; rATG, rabbit; RIC, reduced-intensity conditioning; RTC, reduced-toxicity conditioning; Treo, treosulfan; TDM, therapeutic drug monitoring; UCB, unrelated cord blood; WASp, Wiskott-Aldrich-Syndrome protein.