In the absence of inflammation, the administration of KELIg prior to transfusion effects rapid uptake of opsonized RBCs by red pulp macrophages (RPM; green), inflammatory monocytes (Mono; blue), and CD8⁺ dendritic cells (DC; purple) located within the T-cell zone of follicles (upper panels). In the setting of an inflammatory stimulus [poly(I:C)], there is delayed uptake of opsonized RBCs (lower panels).