Development process for the ASH VTE guidelines. ASH and the McMaster GRADE Centre collaborated to organize, plan, and coordinate the different steps of the guideline-development process. ASH had primary responsibility for budget, topic selection, guideline panel membership, COI management, public consultation, organizational approval, and dissemination. The Systematic Review Working Group (SRWG) worked with guideline panels to prioritize guideline questions and to synthesize and assess the evidence. Guideline panels formulated recommendations and were responsible for writing the guideline reports. The Methods Advisory Group (MAG) advised on and guided methodology for evidence synthesis, formulation of recommendations, and reporting. PICO, population, intervention, comparisons, and outcomes. Adapted from Schünemann et al¹⁵  with permission.