Correlations between the change in ISDI for the TCRβ repertoire and changes in immune-related gene expression in PBMCs resulting from mogamulizumab. The change in ISDI for the TCRβ repertoire is plotted on the x-axis, and the change in expression of each immune-related gene is shown on the y-axis. Blue circles indicate patients without EM, and red circles represent those with EM. HLA-G: rs, +0.422; P = .040; TNFRSF17: rs, +0.350; P = .094; CD8B: rs, +0.803; P < .001; GZMK: rs, +0.668; P < .001; CD40LG: rs, +0.756; P < .001; LRG1: rs, +0.037; P = .866; JCHAIN: rs, +0.368; P = .078; CD8A: rs, +0.719, P < .001; CD4: rs, −0.559; P = .005; CCR4: rs, −0.478; P = .019; and FOXP3: rs, −0.263; P = .213.