Decitabine induces expression of viral antigens in BL xenograft models. (A-B) Immunohistochemistry for EBNA2 and LMP1 in tumors obtained from Mutu I, Kem I, or Rael xenograft mice as indicated. Experiments were performed with 6 mice per condition per cell line for each of the following conditions: vehicle treatment, decitabine 0.5 mg/kg intraperitoneally daily, and decitabine 1 mg/kg intraperitoneally daily. Representative images were obtained on an Olympus BX 43 microscope (Camera, Jenoptik ProgResCF; software, ProgRes Mac Capture Pro, 2013). Original magnification ×600 with a 60/0.80 objective lens. (C-D) Image quantification using HALO (Indica labs). Error bars represent SEM. *P < .05, ** P < .01, ***P < .001, ****P < .0001.