Biomarker analysis for Wnt signaling pathway inhibition. Survivin protein concentrations in plasma vs time and CWP291 concentrations in plasma vs time. (A) Data pooled for the entire study. (B) Data for each cohort. (Note: A LOESS smoothing line is overlaid for survivin. Concentration-time profiles of CWP232204 were also shown for comparison with survivin. Patient 4015 was excluded.)