Mutations in genes and pathways detected at relapse and progression. (A) Gene mutations detected at relapse/progressive disaease (RL/PD) in patients with paired baseline and RL/PD data (n = 74), with genes organized by pathway and patients sorted by best overall response. Blue squares indicate new mutations at RL/PD that were not detected at baseline. Blue squares in the IDH1 mutation row indicate emergent second-site IDH1 mutations at time of RL/PD. Orange squares indicate mutations identified at RL/PD that were also detected at baseline. An X indicates that a variant in that gene that was detected at baseline is no longer detected at relapse. (B) Frequency of emergence of mutations by pathway in patients with data at baseline and at RL/PD (n = 74). CRi, complete remission with incomplete hematologic recovery; CRp, complete remission with incomplete platelet recovery; MLFS, morphologic leukemia-free state; SD, stable disease.