Patient flow diagram summarizing analysis sets. Analyses did not include all patients treated in this population because of several factors, including lack of complete sample availability for all protocol-designated time points and/or suboptimal quantity and/or quality of some samples, resulting in failure to obtain valid data. BMMC, bone marrow mononuclear cell; CDx, companion diagnostic test; DNAseq, DNA sequencing; FDA, US Food and Drug Administration; IDH, isocitrate dehydrogenase; IVO, ivosidenib; PBMC, peripheral blood mononuclear cell; PK, pharmacokinetics; VAF, variant allele frequency.