Enhanced mutagenesis in HBsAg⁺DLBCLs. (A-B) Comparison of the mutation load in the whole genome (A) or coding genome (B) between HBsAg⁺ and HBsAg⁻ DLBCLs. (C) Major mutational signatures were identified according to the 96-substitution classifications from 60 Chinese DLBCLs characterized by WGS. (D) Signatures 2, 6, and 7 were enriched in the HBsAg⁺ samples. Error bars represent standard deviation. A Mann-Whitney U test was used to calculate the P value. Sig, signature.