BRGS^humanmice do not exhibit anemia or thrombocytopenia and have a long lifespan. (A) Frequencies of blood leukocytes, erythrocytes, and platelets in adult B6, BRGS^NOD, and BRGS^human mice. BRGS^human mice have leukopenia resulting from a loss of lymphocytes but have normal numbers of erythrocytes and platelets. (B) Representative flow cytometric plots of blood in B6 and BRGS^human mice. BRGS^human mice lacked T, B, and NK cells. (C) Kaplan-Meyer survival curve of BRGS^human mice (n = 22). ***P < .001.