Figure 5.
Highly activated transferred Tregs express high levels antiproliferative and apoptotic genes. (A) Network diagram of pathway terms from the Hallmark gene set43 enriched in DE gene list up in activated-like transferred Tregs vs aTregs (top). Expression values of genes from pathways in panel A (top) in activated-like transferred Tregs and aTregs (bottom). (B) p53 target49 gene-set scores by UMAP clusters from Figure 4B. (C) Top p53 target genes DE between activated-like transferred Tregs and aTregs manually annotated as antiproliferative, apoptotic, proliferative, antiapoptotic, or other.

Highly activated transferred Tregs express high levels antiproliferative and apoptotic genes. (A) Network diagram of pathway terms from the Hallmark gene set43  enriched in DE gene list up in activated-like transferred Tregs vs aTregs (top). Expression values of genes from pathways in panel A (top) in activated-like transferred Tregs and aTregs (bottom). (B) p53 target49  gene-set scores by UMAP clusters from Figure 4B. (C) Top p53 target genes DE between activated-like transferred Tregs and aTregs manually annotated as antiproliferative, apoptotic, proliferative, antiapoptotic, or other.

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