Delivering GFs within VWF HBD–functionalized fibrin matrices enhances skin wound healing in diabetic mice. Full-thickness back-skin wounds were treated with combined 100 ng of VEGF-A165 and 50 ng of PDGF-BB. Four groups were tested: fibrin only, fibrin functionalized with α₂PI_1–8-VWF HBD only, fibrin containing GFs only, and fibrin functionalized with α₂PI_1–8-VWF HBD containing GFs. After 7 days, (A) wound closure and (B) granulation tissue area were evaluated by histomorphometry (n = 11-13 per treatment group; data are mean ± SEM). Five days after the wound treatment, (C) the frequency of CD31⁺CD45^– ECs within total alive cells and (D) proliferation of SMA⁺CD45^– SMCs assessed by Ki67⁺ marker was determined by using flow cytometry (data are mean ± SEM). *P < .05; **P < .01, ANOVA with Tukey’s test.