VWF promotes growth factor recruitment and wound healing. The HBD of VWF-A1 binds to proangiogenic growth factors, including VEGF-A and PDGF-BB. This interaction promotes sequestration and slow release of growth factors at sites of wound healing to enhance angiogenesis and smooth muscle proliferation, and ultimately, to accelerate tissue repair. Conversely, VWF deficiency results in reduced levels of growth factors at the wound site and delayed wound healing.