LCH imaging. Images demonstrate typical presentation of LCH lesions including (A) single skull lesion on X-ray, (B) vertebra plana on X-ray, (C) femur lesion on X-ray, (D) vertebral lesion on positron emission tomography/computed tomography scan, and (E) cystic lung disease on computed tomography scan. (F) Brain magnetic resonance imaging demonstrates T2 hyperintensity in cerebellum in LCH-associated neurodegeneration. (Courtesy of P. Campbell)