DSP of CD3, CD68, and CD20 regions in DLBCL TME. Representative sample of selected ROIs in 1 case of DLBCL with the same region of tumor demarcated based on CD68 (A; yellow), CD3 (B; red), and CD20 (C; green) ROIs and nuclei/DNA (blue). Original magnification ×20. (D) Average digital counts for LAG3 across all 16 tested cases for CD20, CD3, and CD68, with the CD3 and CD68 ROIs showing significantly higher LAG3 digital protein counts. *P < .05, **P < .01.