Circulating paired soluble LAG3 levels in patients with DLBCL. (A) Paired soluble LAG3 levels at diagnosis (Pre) and after 4 cycles of R-CHOP (Post) compared with healthy subjects (Controls). (B) Paired soluble LAG3 levels in patients whose interim PET/computed tomography (CT) remained positive after 4 cycles of R-CHOP. (C) Paired soluble LAG3 levels in patients whose interim PET/CT was negative after 4 cycles of R-CHOP. *P < .05, **P < .01.