PFS and OS stratified by LAG3. Kaplan-Meier survival curves stratified by LAG3^high or LAG3^low mRNA digital gene counts. PFS (A) and OS (B) for patients in the discovery cohort. PFS (C) and OS (D) for patients in the validation cohort. PFS (E) and OS (F) for patients in the combined discovery and validation cohorts. (G) OS for patients from the combined cohort with high expression of PD-L1 mRNA. (H) OS for PD-L1^high cases in the combined cohort stratified by the LAG3^high prognostic cutoff.