IGHV4-34 gene usage among malignant and normal B cells. The IGHV4-34 gene is used preferentially in many B-cell malignancies, but the bias in PVRL is the most important. Statistically significant differences were observed for comparisons between PVRL and all other malignant or normal B-cell populations (P < .001).^{20,38,39,44,47-50}  BL, Burkitt lymphoma; CBL-MZ, clonal B-cell lymphocytosis of marginal zone origin; CLL, chronic lymphocytic leukemia; HCLc, hairy cell lymphoma classical type; HCLv, hairy cell lymphoma variant type; MCL, mantle cell lymphoma; OAMZL, ocular adnexa marginal zone lymphoma; SMZL, splenic marginal zone lymphoma.